If I use transpose to pose a mesh in Zbrush, and then sculpt away, does it have an undo function that will reset the posing, but keep the sculpting intact?
you can put the pose on a layer at the base level and you should be able to turn it on / off. if that don't fly keep a posed and not posed base to swap in and out at the lowest level which will keep all your high level detail intact. be sure to set a morph target at your highest level before you swap. just in case
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