I'd imagine you'd have the most success in Substance designer, Houdini or Zbrush. Depending on your choice of app the approach would differ, but overall, start with the underlying structure, the "hole" and windows etc, then add the organic tendrils over that.
I would make a few tilebels textures with that organic pattern. So you can blend them together. The easiest way would be Zbrush sculpting, since the surface is very organic in nature. Than use either painter or designer for the res of the maps. Also some heavy displacement once in engine, could make a lot of parallax effect.
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Depending on your choice of app the approach would differ, but overall, start with the underlying structure, the "hole" and windows etc,
then add the organic tendrils over that.