I'm trying to figure out the best way of creating a face with multiple expressions. Namely, my main problem is creating the topology to support it in the lowpoly.
Are there any proven methods of doing this? Is there a "neutral" position my lowpoly should be in (eyes closed, mouth open, etc.)?
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Here is an explanation of topology for animation. Haven't looked through it entirely.
The ideal "neutral" position for your character is "bored". That is, mouth closed, eyes open, no expression whatsoever.
On a side note: If you're looking for something sophisticated for controlling the blend shapes, specifically for lip-sync, etc., FaceFX has been released for UE4 recently: https://unreal.facefx.com/