It really depends on the tools you have on hand. A lot of soft-bodied bags are going to be made in zbrush and then retopologized in max/maya. If you don't have any sculpting program you can still make soft bags but it will just be harder.
Those are 90% sub-d modeling. For the top bag, I did sculpt the crease in the leather where the panels join since that was easier. There might be a better way to do this with cloth sim but I just did it manually with polygons and then used zbrush for a details pass.
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