moose >> People have been talking about the magnification in Windows 8, which is at 150% by default, messing with mouse/UIs. Tried lowering to 125% or 100%?
eq: would snapping your uv's to the pixels help with that? If so it might not fix it 100%, but might be worth a try, as this looks like it might be related to filtering.
"DX display of standard material" I think is the same thing as using the hardware map setting. Not 100% positive, but the effects seem to be pretty close to the same.