If you havn't customized modo a great deal then just delete your .cfg file and it will go back to stock. If you have, consider either re-creating those customizations ( may be fastest way forward) or backing them up using the XPORT_FRAGMENTS script.
One trick is to save what you are working on go into the task manager and kill the modo.exe process. Killing it will act like a crash and revert and changes you made to the UI etc. If you just close Modo the changes get saved to the CFG. One other way is to go to the Layout menu at the top and enable "Lock Thumb Dragging"…