MD to make the base, touch it up in zbrush. there is a few things that are easier to do by hand, like tension folds on something tight like a leather suit. But 90% of time you get most of it done in MD and do small refinements in Zbrush so you aren't spending forever fiddling in MD.
Henlo, ok, so speaking for production creation and in order to get hired by potential client or a company could you explain is it important (and if is why it is important) to know how to sculpt cloth folds manually by hand on a character clothes or it is totally fine if using strictly only marvelous designer to simulate it…