Sharing some images might help others tell what it is that makes these models look 'odd and weird'. It could be something that is tackled directly through Zbrush, or it could be a general art issue like anatomy and proportions. One thing that a lot of new zbrush users usually do is work with more polygons than they need.…
As long as you retopologize the model in the end then it should be perfectly ok for games. It's really just another way to create a model at the end of the day, and you can do this exact same workflow exclusively inside a program like Maya as well. Just don't settle for an automatic retopology solution like ZRemesher for…
This looks like it is a mix of both issues: general anatomy/proportion problems (even if it is meant to be stylized) and the previously mentioned tendency to subdivide way too soon so that you are working with more polygons than needed. It's possible your basemesh might also be making things harder for you since the…