I think there were several memory leaks with Max 2016. I recommend using 2015 or 2017. I worked about a memory leak in 2016 by switching the viewport to OpenGL. But that was kinda lame.
Recently I've been having problems from 3DS Max and I haven't come across many threads talking about the issue. There have been a few on Autodesk's website, but for different versions of the software. Anyway, it would appear as though Max has a very serious issue with hogging resources with every open and close of the UV…