the examples were both made in zbrush. the tiled example was made placing one circle thing at a time. so i told my friend i think substance can do that automatically, but were having no luck reproducing that look.
It wouldn't tile, but I suppose you could send IPackThat tonnes of ngons (maybe randomise their scale beforehand) and disabling rotation but enabling scaling, and let it pack. Then apply the base image using a secondary UV channel or just use a different mesh with the ngons unwrapped around the base image and bake from…
Unless someone has a brilliant insight to do this linearly, this can only be done by using an algorithm that is locally aware. Meaning that it knows that there's empty space of a certain size and can pack shapes until there is no more room, much like how a UV packer works. This would require being able to do programming…
This is typically where the humain brain performs better than an algorithm. Doing that with a computer would require lots of iterations, and it's unfortunately not possible to do in Designer.