Though I don't use it in any 3D package, I've been using StrokeIt for about five years now. It has global actions, application specific actions (it can be a group of apps) and disabled apps. Low memory footprint, simple, just works. To get an idea about some more advanced actions, look at the FAQ, these are the default gestures and here's the forum.
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There's also Just Gestures and gMote.