Am I wrong or is ZBrush still the cheapest route for sculpting? Let me explain. To get to a decent resolution to sculpt detail in Blender, Sculptris, or 3D Coat, you really have to have really high end hardware. From my testing, Zbrush just gives you great performance with relatively low specs. I think the difference in price of ZBrush versus the hardware required for the others, really gives Zbrush a huge edge.
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While the interface can take time to get used to, Zbrush is nice with their license system. With the free updates and the ability to sell your license if you feel you no longer need it. And overall it's price isn't that bad compared to other software.
I actually prefer how its brushes feel and the freedom it gives with those local subdivision/decimation brushes.