If you go for the hard look, yes. I can't really recommend mice anymore since you waste too much time using the eraser or background colors to compensate for the precise hard look you need. Not to mention, many people still can't get Lazy-Nezumi to run in their PS.
im here 100% with Rhinokey hard round and square. sometimes soft round for larger colorgradiations, dont need to do everyone by hand. but handpainted is an area were i would encourage everyone to get creative with looks shaders and brushes alike, so try out new styles. also trying to recreate 2D styles often doesnt realy…