If you're going to try Blender maybe these links will help: http://cgcookie.com/blender/2011/04/11/texture-painting-in-glsl-shading-mode/ http://blenderartists.org/forum/showthread.php?214007-Layers-for-texture-paint-new-addon If you need to learn Blender in general the Blender - What to read up on... thread is a good…
I vouch personally for Mudbox and Blender in this regard. Photoshop is a nightmare. ZBrush is based upon Vertex painting. 3DC has some amazing ideas and killer tech behind it which isn't polished. Also, if you want something free, P-Cel that Ben linked to works wonders, and Blender is free too, but if you something JUST to…
I once tried using Photoshop's 3D capabilities to texture a low-poly model, but I was having a lot of issues with a seam. >: ( I mostly want to be able to paint DIRECTLY onto the model, and I know ZBrush tends to "smooth" the mesh, or display it oddly. (I prefer seeing a low-poly model like you would see in Maya or Max,…