The various 1up podcasts are pretty good. Not gamedev, per se, though: GFW Radio (Shawn Elliot in particular) almost never fails to crack me up. 1up Yours Retronauts is fun if you know the game/franchise they're talking about that week.
SModcast - Kevin Smith and Scott Mosier's podcast. Fun meandering rambles from the dudes who made Clerks, Dogma, Jay and Silent Bob, etc. Modcast - Luxology's weekly modo podcast. Only really relevant if you're a modo user (and even then it can be a bit off-topic). Comic Geek Speak - I occasionally listen to this one. I'm…
Game Theory can be pretty interesting if they have good guests, but I think it kinda went downhill when it branched from Next-gen.biz. I'm sure Colin and Gary are cool guys, but in the podcast they often just come off sounding like pretentious dicks ;) (EDIT: And no, it's not just because of the accents :P) You might want…