The animation is very good overall. I think it looks very natural. But it looks like you're animating the box and the hands seperately from each other. There are points where his right hand kind of floats around and isn't firmly attached to box. You need to either link the hands to the box once he picks it up, or the box…
Daaamn dude thats awesome. Very realistic of you.. hand movements, finger movements.. everything. Well done. No complaints here other than some clipping issue.