I'm highly susceptible to RSI, so I've dealt with that a lot as well. Keyboards and mice are extremely un-ergonomic. The main thing is getting a tablet. Not a display tablet, but one you can lay flat on the desk.It also helps to get a device to replace the keyboard while working, but that's pretty difficult with Blender…
The slowdowns I see with that are: a) you need to be constantly aware of your camera position and in which axis you want to move. That always take me a second of thinking, so it loses out of the box.b) with ZXY, I can never hit the right button without looking down at my keyboard.c) actions that don't need to be precise on…