With PBR workflows, usually not. Unless some dumbass decides to use viewport renderer in c4d or 3DS max. Unless it's unity. Unity has this very distinct deep fried smooth look to it. Something about the color management & lighting system in unity is just outright incorrect. No, it's not just set up wrong, or the wrong use…
I can almost always tell apart sculpts from Blender and Zbrush (when I see a thumbnail on youtube and then check the actual video). And usually 3D games in Unreal or Unity.