As the others mentioned, many settings can be stored via the <Preferences:Store Config>, or <Document:Save as Startup Doc> (for canvas related settings. There is also the "ZStartup Master" plugin, that is part of the ZBrush 2018 installation, which can be found in the Zplugin palette. Now the Grp button is an interessting…
Unfortunately its a bit of a mess since different settings are stored in different places. And while you can use a start-up macro/script to automatically set certain toggles and preferences for you... you might find that half of them get wiped when you load a project that has its own stored settings. In the case of the Grp…