@somedoggy sorry, I should have been more specific. In the OP's case I'm talking about a basic character pre-made game topology mesh being ported to ZB for sculpting and polypainting (which I assumed from the original, somewhat confusing, post) Obviously there are more specialised cases, as you've mentioned, and…
I think you have yourself confused. When you talk about the game mesh and the sculpting mesh they are one and the same in a zbrush subdiv levels workflow. Both the lowest level uvs and topology propogate up through the levels. Yes, subdividing a mesh can warp uvs(linear vs smooth uvs) Zbrush has a smooth uvs function. But…