Closest to Zspheres in Blender is probably the Skin modifier or Metaballs. https://www.youtube.com/watch?v=W0ySG59xkyshttps://www.youtube.com/watch?v=pXAqeyaABYI
Does it work the same for installing pip for Blender's bundled Python? Specifically, the instructions here. This is a link to the current github page for the add-on.