http://www.filterforge.com/ It definetly takes away from that fun time hand painted look. But i could see that node system being very handy when you're in a bind.
Look at an anatomy chart with the circulatory system. Add to that lots of pictures of people with different complexions and should be able to deduce from there.
Live action segments filmed in stereo, it's as 3d as it gets. They even developed the camera system for it: http://en.wikipedia.org/wiki/Fusion_Camera_System