man, please don't take this the wrong way this is beast. But do you think the triceps need some definition if his biceps are that defined? (just 2cents)
great start, i think it would be cooler if she was more petite though. that specific body build seems to be one of defining characteristics of original design.
Latest ingame shot is fantastic, I had to double take. The way the specular/reflection catches on the scales is beautiful, the eye colour change is definately an improvement :)
If she's wearing a hooded sweatshirt her boobs are not going to be that defined. Take a look at how the fabric lays over her chest in the reference you posted.
Those extra edge loops don't define a silhouette really. You can easily take these out and lessen the polycount. There's no reason to have them in there at the moment.
If you store a morph target then use the layer brush, all strokes will stop at a maximum height defined by the brush strength. See if that's what you're after.
Additionally, you may want to define the space between the barrel and the slide, as right now it looks like the slide's geometry is intersecting with the barrel. Reference attached: