im running a 32" and a 21". Before the 32(my tv), i had a 19 full, because i didnt have a widescreen tablet. I never had an issue. You get use to whatever you have
24" and 19" here, the first being 1920x1200 and the second one being 1280x1024. it never has been a problem, is an ideal setup and works just fine. even at work my screens are of different size and resolution. I actually find it more usefull that way as it gives you a clear center of attention and helps in organizing stuff…